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Microscopically, the treated animals retained more axons and showed less white matter damage
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In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis
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doi: 10.2119/molmed.2015.00040 73 AsadipourMHassan-ZadehVAryaeianNShahramFMahmoudiM
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